Objective To evaluate the clinical value of B ultrasound examination combined with serum cancer antigen 125 ( CA125 ) in differential diagnosis of malignant tumors from benign tumors.Methods Retrospective analysis was conducted on B ultrasound examination and serum CA125 detecting results of 98 cases of ovarian tumors confirmed by pathological examination, including 47 cases of malignant ovarian tumor and 51 cases of benign tumors.The clinical value of the combination of two methods in diagnosis of ovarian benign and malignant tumors was evaluated.Results B ultrasound examination showed that there was no significant difference in size of benign and malignant ovarian tumors (P>0.05), but the differences in texture, shape, location and capsule were significant (χ2 value was 17.814, 7.500, 5.226 and 25.246, respectively, all P<0.05).CA125 level of benign ovarian tumors was 21.74 ±12.15IU/mL, which was significantly lower than that of ovarian cancer (254.20 ±189.40IU/mL), and the difference was statistically significant (t=8.395, P<0.05).With B ultrasound examination, the sensitivity, specificity, misdiagnosis rate and rate of missed diagnosis was 76.60%, 76.47%, 23.53% and 24.40%, respectively with Kappa of 0.530, while they were 68.09%, 66.67%, 33.33% and 31.91%, respectively with Kappa of 0.347 with CA125.When combining two methods, they were 89.36%, 84.31%, 15.69% and 10.64%, respectively with Kappa of 0.735.Conclusion Serum CA125 combined with B ultrasound examination can significantly improve the differential diagnosis of benign and malignant ovarian tumors.%目的：评估B超检查结合血清癌坯抗原125（ CA125）检测在鉴别诊断妇女卵巢良、恶性肿瘤中的临床价值。方法对98例经过病理检查确诊的卵巢肿瘤患者的B超检查结果、血清CA125检查结果进行回顾性分析，其中包含47例恶性卵巢肿瘤患者、51例良性肿瘤患者。对两种方法联合诊断妇女卵巢良、恶性肿瘤的临床价值进行评估。结果在B超检查下，良、恶性卵巢肿瘤的大小差异无统计学意义（P＞0．05）；良、恶性卵巢肿瘤的质地、形状、位置、包膜在超声下表现差异均具有统计学意义（χ2值分别为17．814、7．500、5．226、25．246、均P＜0．05）。卵巢良性肿瘤的CA125值为21．74±12．15IU／mL，显著低于卵巢恶性肿瘤的254．20±189．40IU／mL，差异有统计学意义（t ＝8．395，P ＜0．05）。 B 超检查诊断卵巢恶性肿瘤的灵敏度为76．60％、特异度为76．47％、误诊率为23．53％、漏诊率为24．40％、Kappa＝0．530。 CA125检查诊断卵巢恶性肿瘤的灵敏度为68．09％、特异度为66．67％、误诊率为33．33％、漏诊率为31．91％、Kappa＝0．347。 B超联合CA125检查诊断卵巢恶性肿瘤的灵敏度为89．36％、特异度为84．31％、误诊率为15．69％、漏诊率为10．64％、Kappa＝0．735。结论 B超检查结合CA125可以显著的提高鉴别诊断卵巢良恶性肿瘤的临床价值。
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