Objective To explore the relationship between illness uncertainty and anxiety as well as depression in cervical cancer patients undergoing radiotherapy .Methods Hospital Anxiety and Depression Scale ( HADS) and Mishel Uncertainty in Illness Scale ( MUIS) were used to investigate 68 cervical cancer patients .Results The total score of MUIS was 93.06 ±7.91.The average score of HADS-A was 6.90 ±3.50 and HADS-D was 6.26 ±4.06.The prevalence of depressive disorders , anxiety disorders, and comorbidity of both disorders was 39.7% (27), 35.3% (24) and 26.47% (18), respectively.HADS-A was positively correlated with total score of illness uncertainty and ambiguity (r=0.374,P=0.002;r=0.526,P=0.000).HADS-D was positively correlated with total score of illness uncertainty, ambiguity and inconsistency (r=0.381,P=0.001;r=0.397,P=0.001;r =0.318,P=0.009).Unpredictability was negatively correlated with HADS-A and HADS-D (r=-0.355,P=0.003;r=-0.272,P=0.026).Conclusion Illness uncertainty is closely related with the feeling of anxiety and depression in cervical cancer patients undergoing radiotherapy .Doctors and nurses should attach concerns to the uncertainty of the patients , and reduce illness uncertainty , anxiety and depression by providing more relevant information .%目的：描述放疗期间宫颈癌患者疾病不确定感水平及焦虑抑郁状况；探讨疾病不确定感与焦虑、抑郁之间的关系。方法应用医院焦虑抑郁量表（ HADS）、疾病不确定感量表（ MUIS）对68例放疗期宫颈癌患者进行调查。结果放疗期间宫颈癌患者疾病不确定感总得分为（93．06±7．91）；焦虑得分为（6．90±3．50）分，抑郁得分为（6．26±4．06）分；焦虑（HADS-A≥8）27人（39．7％），抑郁（HADS-A≥8）24人（35．3％），焦虑合并抑郁18人（26．47％）；疾病不确定感总分、不明确性与焦虑呈正相关（r＝0．374，P＝0．002；r＝0．526，P＝0．000）；疾病不确定感总分、不明确性、信息缺乏性与抑郁呈正相关（ r＝0．381，P＝0．001；r＝0．397，P＝0．001；r＝0．318，P＝0．009）；不可预测与焦虑、抑郁均呈负相关（r＝-0．355，P＝0．003；r＝-0．272，P＝0．026）。结论放疗期宫颈癌患者疾病不确定感与焦虑抑郁密切相关，医护人员应关注并了解患者的疾病不确定感，通过针对性地提供相关信息，降低患者的疾病不确定感，以降低患者的焦虑抑郁水平。
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