Objective To analyze the risk factors of placental abruption (PA) in patients with preeclampsia (PE), so as to provide reference for the prevention of the disease .Methods From June 2010 to September 2013 268 cases with PE delivering in the maternity department of Jintai Hospital of Baoji City in Shaanxi Province were selected , including 48 cases combining PA in observation group and the other 220 cases not combining PA in control group .Clinical data of two groups were retrospectively analyzed , and the factors were analyzed with univariate analysis and multivariate Logistic regression analysis .Results Univariate analysis showed that the gestational age , fibrinogen (FIB) and serum albumin (ALB) in the observation group were significantly decreased than those in the control group (t value was 2.059, 3.591 and 8.200, respectively, all P<0.05), but diastolic pressure (DBP), blood urea nitrogen (BUN), creatinine (Cr) and 24h urine protein (24h UP) were significantly increased (t value was 2.652, 4.583, 6.852 and 3.632, respectively, all P<0.05).The childbirth history in the observation group was significantly lower than that in the control group (χ2 =8.731,P<0.05).Multivariate Logistic regression analysis showed that FIB , 24h UP, ALB, Cr and childbirth history were the independent risk factors for PE combining PA (OR value was 1.369, 1.198, 1.205, 1.283 and 1.231, respectively, all P<0.05).Conclusion The pathological mechanism of PA combining PE is complex, and it is related with FIB, 24h UP, ALB, Cr and childbirth history.The high-risk factors of PA should be found as early as possible in clinics , and effective measures should be taken to prevent the occurrence of PA .%目的：对子痫前期（ PE）患者胎盘早剥（ PA）的相关危险因素进行分析，以期为预防此类患者的胎盘早剥提供依据。方法选择2010年6月至2013年9月在宝鸡市金台医院产科分娩的PE产妇268例，其中48例合并PA作为观察组，而另外220例未合并PA的患者作为对照组。回顾性分析两组患者的病例资料，对相关因素进行单因素分析及多因素Logistic回归分析。结果单因素分析结果显示，观察组孕周、纤维蛋白原（FIB）和血清白蛋白（ALB）显著低于对照组（t值分别2．059、3．591、8．200，均P＜0．05），而舒张压（DBP）、尿素氮、肌酐、24h尿蛋白（24h UP）显著高于对照组（t值分别2．652、4．583、6．852、3．632，均P＜0．05），观察组患者分娩史显著低于对照组（χ2＝8．731，P＜0．05）。多因素Logistic回归分析结果显示，FIB、24hUP、ALB、肌酐和分娩史是PE合并PA的独立危险因素（OR值分别为1．369、1．198、1．205、1．283、1．231，均P＜0．05）。结论 PE患者发生PA的病理机制复杂，与FIB、24hUP、ALB、肌酐和分娩史有关，临床工作中应尽早发现PA发生的高危因素，采取有效措施进行预防。
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