Objective To analyze the types of bacterial infection and predisposing factors of neonatal sepsis , so as to provide guidance for prevention and treatment of neonatal sepsis .Methods A retrospective analysis was carried out on 64 sepsis cases hospitalized in Shangluo Central Hospital during the period of October 2009 to December 2011.Their blood cultures were positive .Etiological factors, routes of infection and pathogens of neonatal sepsis were reviewed .Results Premature rupture of membranes (18, 28.1%), premature infant(29, 45.3%), prolonged labor stage(29, 45.3%) and prenatal fever(8, 12.5%)were the predisposing factors for early onset neonatal sepsis . Neonatal omphalitis(9, 14%) and skin impetigo(7, 10.9%) were closely associated with the incidence of late onset neonatal sepsis .Of 39 cases with Gram-negative bacteria (60.9%) Escherichia coli were predominate , followed by Klebsiella pneumoniae (13, 33.3%). There were 25 cases with Gram-positive cocci(39%), including Staphylococcus aureus (11, 44%) and Staphylococcus epidermidis (5, 20%) .Conclusion Early-onset and late-onset sepsis have different predisposing factors and they are caused by different types of pathogens.Patient care should be strengthened and strict aseptic treatment should be implemented .Antibiogram should be carried out in order to select effective medicine specific to the etiologic pathogens .%目的分析新生儿败血症的感染细菌的种类、易感因素。为新生儿败血症的预防和治疗提供借鉴。方法回顾性分析商洛市中心医院2009年10月至2011年12月住院治疗的64例血培养阳性新生儿败血症患儿的临床资料，对新生儿败血症的致病因素、感染途径、病原菌种类进行统计分析。结果发现胎膜早破18例（28．1％）、早产儿29例（45．3％）、产程延长29例（45．3％）、产前发热8例（12．5％）为新生儿早发型败血症易感因素；新生儿脐炎9例（14％）、皮肤脓疱疮7例（10．9％）与晚发型新生儿败血症的发病有着密切关系。血培养病原菌中革兰氏阴性菌39例（60．9％）大肠埃希氏菌占首位，其次是肺炎克雷伯杆菌13例（33．3％）；革兰氏阳性球菌25例（39％），主要为金黄色葡萄球菌11例（44％），表皮葡萄球菌5例（20％）。结论早发型败血症和晚发性败血症的易感因素、病原种类不同，应加强护理、严格无菌操作，治疗中应根据病原菌及其耐药性检测选用敏感药物治疗。
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