Objective To investigate the function and relevance of the level of serum leptin ( LP ) and reproductive hormone in patients with polycystic ovarian syndrome ( PCOS ). Methods The level of serum LP was tested by enzyme linked immunoabsorbent assay ( ELISA ) and the level of reproductive hormone was tested by chemical luminescence method. The correlation between them was analyzed. Results The level of LP, luteinizing hormone ( LH ), LH/ follicle-stimulating hormone ( FSH ) and testosterone ( T ) in PCOS group were higher than those in control group ( t value was 5.40, 7. 19, 6. 93 and 3. 70, respectively, all P <0. 05 ). The level of LP was positively correlated with LH, LH/FSH and T in PCOS patients( r value was 0. 571, 0. 462 and 0. 653 , respectively, all P <0. 05 ). Conclusion W level and reproductive hormone may play an important role in happening and development of PCOS, and they are correlated with each other.%目的 研究瘦素和生殖激素水平在多囊卵巢综合征(PCOS)发病过程中的作用及相关性.方法 采用酶联免疫吸附试验法检测瘦素水平,化学发光法检测生殖激素水平,并分析它们之间的相关性.结果 多囊卵巢综合征组的瘦素、黄体生成激素、黄体生成激素与卵泡刺激素的比值和睾酮水平高于对照组(t值分别为5.40、7.19、6.93、3.70,均P<0.05),且瘦素与黄体生成素、黄体生成素与卵泡刺激素比值、睾酮呈正相关(r值分别为0.571、0.462、0.653,均P<0.05).结论 瘦素与生殖激素可能在多囊卵巢综合征的发生发展中起到重要作用,且有一定的相关性.
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