Objective To observe therapeutic effect and safety of oral ibuprofen for patent ductns arteriosus (PDA) in preterm infants.Methods 40 preterm infants with PDA were orally given 10 μg· kg-1 ·d-1 of ibuprofen for consecutive 3 days. Before and after treatment,blood mutine examination, liver and renal functions and electrolytes of the preterm infants were examined, and echocardiography was reexamined after treatment. Results Of 34 preterrn infants with closed ductus arteriesus, 1 preterm infant was complicated with pulmonary hypertension. Before and after treatment, in PLT, serum levels of creatinine, urea nitrogen of the preterm infants there were no significant differences (t =0. 113, 0. 957, 0. 342 respectively, all P ＞ 0. 05 ). The curative rate of ibuprofen for PDA of preterm children was 89.47％, and the effective rate was 94.74％. Conclusion After oral administration of ibuprofen for treatment of PDA, the preterm infants had no bleeding, liver and kidney dysfunctions and vomiting, abdominal distension and other gastrointestinal symptoms, but its long-term prognosis and changes in pharmacokinetics need to be studied further.%目的 观察口服布洛芬治疗早产儿动脉导管未闭(PDA)的临床疗效与安全性.方法 选取符合要求的早产儿40例口服布洛芬(10mg·kg-1·d-1)共3天,用药前后查血常规及肝肾功能;用药后再次复查心脏彩超.结果 34例动脉导管关闭患儿中,1例出现肺动脉高压,治疗前后血小板、肌酐、尿素水平比较均无显著性差异(t值分别为0.113、0.957、0.342,均P>0.05),布洛芬治疗早产儿动脉导管未闭的治愈率为89.47%,有效率为94.74%.结论 口服布洛芬治疗早产儿动脉导管未闭中未发现患儿出血、肝肾功能损害及呕吐、腹胀等消化道反应,但远期预后及药代动力学改变有待进一步研究.
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