目的 了解导致盆底器官脱垂早发的可能影响因素.方法 选择2010年1月～12月就诊于南京军区福州总医院≤45岁的盆底器官脱垂患者42例(低龄早发组),并与同期入院的43例≤45岁无盆底器官脱垂患者(对照组)和52例>45岁的高龄盆底器官脱垂患者(高龄组)进行比较,并分析不同的影响因素.结果 有盆底器官脱垂家族史者出现早发器官脱垂的危险性是无家族史的8.228倍(95%CI:1.555～43.548,P=0.013);产次>2次者能使低龄妇女发生盆底器官脱垂的危险系数增加5.108倍(95%CI:1.703～15.317,P=0.004).疝气和静脉曲张在低龄早发组的发生率较无脱垂对照组高,但差异无统计学意义(均P>0.05);此外,高龄组的平均身体质量指数高于低龄早发组(t=-3.348,P=0.001),但其家族史比例低于低龄早发组(χ2=9.734,P=0.002).结论 家族史可能是盆底器官脱垂早发的重要因素;随着年龄的增长,多次分娩带来的盆底损伤在体重超重等诱发因素的作用下可能增加了老年妇女盆底器官脱垂的发病风险.%Objective To explore the possible factors which may lead to early-onset of pelvic organ prolapse ( POP ). Methods From January to December 2010, 42 patients younger than 45 with POP were compared with 43 patients younger than 45 without genital prolapse and 52 patients older than 45 with genital prolapse adopted in corresponding period in Fuzhou General Hospital. Statistic methods were used to analyze the influencing factors. Results Women with famil history were probably 8. 228 times in developing early-onset genital prolapse ( 95％ CI: 1. 555-43. 548, P= 0. 013 ) to those without family history, and parity more than 2 times might increase the risk in young women ( 95％CI:1. 703-15. 317, P =0.004 )by 5. 108 times. The prevalence of hernia and varicose vein was relatively higher in the early-onset POP patients, but there was no statistical significance ( all P ＞ 0.05 ). Besides, the mean body mass index of older genital prolapse patients was higher ( t= - 3. 348, P= 0. 001 ), but the proportion of family history was lower (x2 = 9. 734, P= 0. 002 ). Conclusion Family bistory may be an important factor leading to early-onset of POP. With age increasing and effect of overweight, the injury caused by multiple parities may increase the risk of POP in older women.
展开▼
