RhoA属于小 G 蛋白 Rho 亚家族，在细胞的增殖、迁移、黏附及凋亡等过程中发挥重要的调控作用。国内外近期研究发现，一方面RhoA/ROCK通路可通过影响心肌能量代谢、炎症反应、内质网应激等在心肌缺血/再灌注中造成心肌损伤，另一方面， RhoA的激活对再灌注损伤也具有积极作用。该文对近年来RhoA在心肌缺血/再灌注中的调控作用及机制作一综述，并探讨其作为治疗心肌缺血/再灌注损伤的药物靶点的应用前景，为研发心肌缺血/再灌注损伤治疗药物及其用药策略提供理论依据。%RhoA belongs to the small G binding proteins Rho subfamily, playing an important role in the various cellular func-tions, including migration, proliferation, adhesion and apopto-sis. Recent data indicate that RhoA/ROCK pathway causes myo-cardial damage by influencing the myocardial energy metabolism, inflammation, and endoplasmic reticulum stress. On the other hand, the activation of RhoA also has a positive role in MIRI. This article reviews the regulatory effect of RhoA on MIRI and its mechanisms, discusses the prospects of RhoA as a novel thera-peutic target for MIRI, and provides new therapeutic treatments and strategies for MIRI.
展开▼
