Anti-fever Chinese herb is a kind of common used Chinese medicine in clinical treatment of ischemic heart disease. In recent years, it is reported in many literature that single herb, such as coptis chinensis, scutellaria baicalensis, honeysuckle, polygonum cuspidatum, radix paeonia rubra and herba lo-phatheri, and the compound, such as honeysuckle preparations and huanglian jiedu decoction, have distinct effect of reducing myocardial infarct area on rats. The mechanism of these herbs and compound prescription has multifaceted roles, such as an-tioxidative response, improving mitochondrial features, and inhibiting apoptosis of myocardial cell, etc. Nowadays, ischemic cardiovascular diseases have become a major disease and a serious threat to people's lives in our country. The research of pharmaceutical effect and mechanism of anti-fever Chinese herbs would lay a solid foundation for developing effective and safe Chinese medicine for prevention and treatment of cardiovascular disease.%清热类中药为中医临床防治缺血性心脏病的常用中药之一.近年来,许多文献报道表明,清热类中药中的黄连、黄芩、金银花、虎杖、赤芍、竹叶,以及复方中的金银花制剂、黄连解毒汤等对于心肌缺血模型动物具有明显的减少心肌梗死面积的作用,其作用机制涉及多个方面,如抗氧化应激反应、改善细胞线粒体功能、抑制心肌细胞凋亡等.在缺血性心血管疾病已成为严重威胁我国人民生命安全的重大疾病的今天,对于清热类中药防治心血管疾病的药理作用和机制研究,将为开发高效、安全的防治心血管疾病的中药新药奠定坚实的基础.
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