Endoplasmic reticulum (ER), the largest intracellular organelles is associated with protein modification, folding and calcium store.The accumulation of unfolded protein and disorder of calcium can lead to ER stress.Endoplasmic reticulum stress-induced apoptosis is closely related to mary diseases.Studies have shown that simulation of the unfolded protein response to suspend protein synthesis or interfere with biological macromolecules accelerating apoptosis to against apoptosis,brining about the protection in ER stress related cell injury and interfering with related diseases.%内质网( endoplasmic reticulum,ER)是细胞内最大的细胞器,是蛋白质修饰、折叠和钙贮存的场所.ER内未折叠或错折叠蛋白积聚和钙平衡失调可导致 ER应激.ER应激及其诱导的凋亡与许多疾病的发生发展密切相关.研究显示,模拟未折叠蛋白反应使蛋白质合成暂停或干预促凋亡的生物大分子能够对抗凋亡,实现ER应激诱发损伤的保护以及相关疾病的干预.
展开▼
