目的 研究化合物YX0611-1对神经病理性疼痛大鼠的镇痛作用.方法 建立CCI模型,采用Electronic von Frey法和热辐射法分别测定大鼠机械刺激缩足反射痛阈值(MWT)和热刺激缩足反射潜伏期(TWL).结果 YX0611-1 160 mg·kg-1组和80 mg·kg-1组单次给药均能明显提高大鼠的机械刺激阈值,延长大鼠热刺激潜伏期;YX0611-1 160 mg·kg-1组多次给药能明显提高大鼠机械刺激阈值,延长大鼠热刺激潜伏期;YX0611-1 80 mg·kg-1组多次给药能明显提高大鼠的热刺激潜伏期.结论 化合物YX0611-1对神经病理性疼痛大鼠有镇痛作用.%Aim To explore the anti-nociceptive effect of compound YX0611-1 in rats with a sciatic nerve chronic constriction injury ( CCI ). Methods CCI model was performed as four ligatures placed around the fight sciatic nerve and tied without obstructing the blood supply of the nerve. Thermal withdrawal latency ( TWL )and mechanical withdrawal threshold( MWT )of rats were determined by Hargreaves thermal radiation apparatus and electronic von Frey's method of microfilament, respectively. Results YX0611-1 significantly reversed the reduction of mechanical and thermal hyperalgesia thresholds at doses of 80 mg · kg-1 and 160 mg · kg -1 after single gavage. Similar with the results of single gavage, the mechanical and thermal thresholds were also significantly enhanced at both doses after consecutive gavages, with the exception that YX0611-1 had no effect on mechanical threshold at 80 mg · kg-1. Conclusion In rat with neuropathic pain, compound YX0611-1 exerts analgesic effect.
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