The H2O2 has been shown to have comprahensive actions on various ion channels of cell membrane. But it has different effects on different tissues. H2O2-induced a dose dependent decreasing L- type Ca2+ current on cultrued Lymnaea neurons. In sheep cardiac SR, H2O2 plays an important role in regulating directly on RyR Ca2+-release channel that caused an increasing of P0, but it was no effects on conductance. It indicated that H2O2-induced different activities on KCa channel with different tissues. In guinea pig ventricular myocytes, H2O2-induced increase in KATP channels. There are few data on the effects of H2O2 on whole cell Na+ currents and single Na+ channels.%H2O2对细胞膜上不同的离子通道有广泛的作用, 而且同一种通道在不同的组织类型中对H2O2的反应性亦不同。在培养的lymnaea（椎螺）神经元中，H2O2可诱导剂量依赖性的内向Ca2+电流的降低，L-型Ca2+电流的降低,导致通道失活。在绵羊心肌细胞的内质网H2O2可直接调节Ca2+释放通道，使其开放概率（P0）增加，但它不影响电导。H2O2对K＋通道的作用表明，H2O2介导的KCa通道活性改变因组织类别的不同而亦有差异。H2O2可诱导豚鼠心肌细胞ATP-敏感K＋通道的活动增加。H2O2对全细胞Na+通道的影响及对单通道Na+电流的影响目前报道极少。
展开▼
