Objective To explore the diagnosis and treatment of solitary plasmacytoma of bone (SPB) and to summarize its clinicopathological features. Methods The clinical data of 10 SPB patients were retrospectively ana-lyzed. The clinical features, diagnostic criteria, treatment and prognosis were summarized. Results All the 10 pa-tients were confirmed by pathology as SPB and fulfilled the diagnostic criteria. The average age of onset was 54 years. Seven patients received radiotherapy after operation. The follow-up ranged from 5 to 120 months. The median follow-up time was 37.5 months. One patient had local recurrence, and another progressed into multiple myeloma (MM). Two patients died of infection. The 5-year survival rate was 70%. Conclusion SPB is more likely to occur in middle-aged and elderly patients. As a rare low-grade malignant tumor, SPB is confirmed mainly by pathology and usually presents with a favorable prognosis. Some patients may progress into MM. Radiotherapy at a proper dose combined with surgery may be the optimal choice of treatment.%目的 探讨骨孤立性浆细胞瘤(SPB)的诊断和治疗,总结其临床病理特点.方法 回顾性分析10例SPB患者的临床资料,并对其临床特点、诊断标准、治疗和预后进行总结.结果 10例患者均经病理证实为SPB并符合其诊断标准,中位发病年龄54岁,7例患者术后接受放疗.随访5~120个月,中位随访时间为37.5个月,其中1例局部复发,1例进展为多发性骨髓瘤(MM),2例患者感染死亡,5年生存率为70%.结论 SPB好发于中老年,是少见的低度恶性肿瘤,主要依靠病理确诊,预后较好,部分可转化为MM.适当剂量的放疗结合手术可能是其治疗的最佳手段.
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