目的：研究共轭亚油酸降低血脂及抑制动脉粥样硬化炎症反应的作用。方法将45只ApoE-/-小鼠按空腹体质量随机分为3组：①共轭亚油酸组，给予含2％共轭亚油酸的高脂饲料；②高脂模型组，给予单纯高脂饲料；③普通对照组，给予普通饲料。干预12周后，检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）水平，采用酶联免疫吸附试验（ELISA）法测定小鼠血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β和IL-10水平。结果①共轭亚油酸组血清TC、TG水平与高脂模型组相比显著降低高（P＜0．05），HDL-C水平差异无统计学意义（P＞0．05）；②共轭亚油酸组血清TNF-α、IL-1β水平与高脂模型组相比显著降低（P＜0．05），而IL-10则显著升高（P＜0．05）。结论共轭亚油酸具有降低血脂和抗动脉粥样硬化炎症反应的作用。%Objective To investigate the effect of conjugated linoleic acid in decreasing blood lipid and inhibit-ing inflammatory response of atherosclerosis. Methods Forty-five ApoE-/-mice with empty stomach were randomly di-vided into three groups according to weight: ① the conjugated linoleic acid (CLA) group, given high-fat diet contain-ing 2% CLA; ② high-fat model group, given simple high-fat diet; ③ normal control group, given standard diet. After 12 weeks of intervention, the levels of serum total cholesterol (TC), total triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured. The levels of serum tumor necrosis factor-α (TNF-α), interleukin (IL)-1β IL-10 were measured by ELISA. Results ① The serum TC and TG levels in the CLA group were significantly decreased compared with those in the high-fat model group (P0.05).②The serum TNF-αand IL-1βlevels in the CLA group were significantly de-creased compared with those in the high-fat model group (P<0.05), whereas the IL-10 level was significantly increased (P<0.05). Conclusion CLA may decrease blood lipid and inhibit inflammatory response of atherosclerosis.
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