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>Structure and functions of transcriptional coactivators p300/CBP and their roles in regulation of interleukin gene expression
Structure and functions of transcriptional coactivators p300/CBP and their roles in regulation of interleukin gene expression
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摘要
p300/CBP are versatile transcriptional coacti- vators that participate in many physiological processes, in- cluding cell cycle control, differentiation and apoptosis. p300/CBP possess histone acetyltransferase (HAT) activity and they are involved in transcriptional regulation by acety- lating histone and nonhistone proteins. Moreover, they act as protein bridges connecting specific transcription factors to the basal transcription machinery and provide a scaffold to integrate multiple transcription cofactors. Several studies suggest that p300/CBP may serve as tumor suppressors since mutations or translocations in p300/Cbp genes have been observed in a number of cancers. Furthermore, in many neurodegenerative diseases, inhibition of p300/CBP function may be one of the underlying causes of cytotoxicity. Several studies have demonstrated that p300/CBP are implicated in the regulation of many interleukin genes. This review focuses on the structures and functions of p300/CBP and their roles in the regulation of interleukin genes based on the work per- formed in our laboratory.
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机译：Structure Determination and Mechanistic Insights of: I.Cyanobacteriochrome NpR6012g4 Light Sensor Protein in Phototaxis II.Retinal Degeneration 3 (RD3) Protein in Vision III.Ryanodine Receptor 2 (RyR2) Regulation by Calmodulin (CaM) in Cardiac Function =结构测定和机理洞悉：I.趋光性中的蓝细菌色素NpR6012g4光敏蛋白 II.视觉作用中的视网膜退化蛋白3 III.心脏功能中的钙调蛋白调控兰诺定受体2
