目的 探索血红素加氧酶-1(HO-1)水平与一氧化碳(CO)水平在肺炎支原体感染患儿中的变化及临床意义.方法 选择该院2013年10月至2015年6月确诊并收治的219例肺炎支原体感染患儿为研究对象,根据急性期是否伴有喘息将其分为无喘息组(156例)和有喘息组(63例),而有喘息组患儿根据有无低氧血症而分为轻症喘息组(39例)和重症喘息组(24例).采用酶联免疫吸附法测定血HO-1水平,采用双波长分光光度法测定破氧血红蛋白百分比(COHb％),分析各组间差异.结果 有喘息组患儿血COHb比例2.59％士0.40％和HO-1水平(1 813.24士28.34)ng/L与无喘息组比较均有明显增加,组间差异有统计学意义(P＜0.05).重症喘息纽患儿COHb比例3.63％士0.45％和HO-1水平(2594.34±23.94)ng/L与轻症喘息组比较均有明显增加,组间差异有统计学意义(P＜0.05).血COHb比例和HO-1水平呈正相关(r=0.733,P＜0.05).结论 CO和HO-1可能参与肺炎支原体感染患儿喘息的发病过程,应引起临床的高度重视.%Objective To explore the heme oxygenase-1 (HO-1) content of carbon monoxide (CO) levels and clinical significance of Mycoplasma pneumoniae infection in children.Methods 219 cases of mycoplasma pneumonia from October 2013 to June 2015 in our hospital were divided into two groups,which were non-asthmatic group (156 cases) and wheezing group (63 cases),and the wheezing group were divided into two groups according to the presence or absence of hypoxemia and mild asthmatic group (39 cases) and severe asthmatic group (24 cases).HO-1 content in the blood was measured by enzyme-linked immunosorbent assay,using dual-wavelength spectrophotometric determination of hemoglobin oxygen percentage of broken (COHb％),analysis of the differences between the groups.Results Children with blood COHb content wheezing group were (2.59 ± 0.40)％ and HO-1 levels were (1 813.24 ± 28.34)ng/L and non-respite group were significantly increased,it had significant differences between the two groups (P＜ 0.05).Group of children with severe wheezing COHb content were (3.63 ± 0.45)％ and HO-1 levels were (2 594.34±23.94)ng/L and mild wheezing group were significantly increased,it had significant differences between the two groups (P＜0.05).Positive correlation between blood COHb content and HO-1 levels were significantly (r=0.733,P＜0.05).Conclusion Mycoplasma pneumoniae infection in children with wheezing blood COHb content and HO-1 levels were significantly increased,and with wheezing exacerbation and showed an increasing trend,suggesting that CO and HO-1 may be involved in Mycoplasma pneumoniae infection in children in the pathogenesis of wheezing,should lead to clinical attention.
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