Objective To investigate the distribution and antibiotic resistance of clinical isolates of pathogenic bacteria in a hospital of Chongqing from 2008 to 2010.Methods 8 921 samples were collected from a hospital of Chongqing.Identification of bacteria and susceptibility tests were performed by using MicroScan A/s-4 system.Results A total of 3 822 clinical samples were analyzed,and 42.84％ of these were bacteria-positive.According to statistical analysis,the clinical isolates in the top five were Pseudomonas aeruginosa (677cases),Baumann/hemolysis Acinetobacter (648 cases),Klebsiella pneumonia (494cases),Escherichia coli strains (491cases),and Staphylococcus aureus (215cases).And the Results revealed that antibiotic resistance of the five pathogens to most antimicrobial increased year by year.The resistance of Baumann/hemolysis Acinetobacter,Klebsiella pneumonia,Escherichia coli and Staphylococcus aureus to antimicrobial agents were higher than others,and the antibiotic sensitivity in Pseudomonas aeruginosa was about 45％.In addition,the positive rate of Baum?nn/hemolysis Acinetobacter increased fast in three years.Conclusion Periodically bacterial resistance surveillance and bacterial resistance database establishment are of great importance for clinically rational application of antibiotic.%目的 分析2008～2010年重庆市某院临床分离病原菌分布及其耐药情况.方法 收集该院临床送检标本8 921份,采用Micro Scan A/s-4系统进行细菌鉴定和药敏试验.结果 细菌培养阳性3 822份,阳性率为42.84％,经统计,临床分离菌处于前5名的是:铜绿假单胞菌(677例)、鲍曼/溶血不动杆菌(648例)、大肠埃希菌(494例)、肺炎克雷伯菌(491例)、金黄色葡萄球菌(215例)；对大多数药物耐药率较高的有鲍曼/溶血不动杆菌、肺炎克雷伯菌、大肠埃希菌以及金黄色葡萄球菌,铜绿假单胞菌对各种药物的敏感性平均为45％；另外鲍曼/溶血不动杆菌的检出率上升很快,有超过铜绿假单胞菌的趋势.结论 建立该院细菌耐药数据库,为临床上合理应用抗菌药物具有重大意义.
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