Objective To evaluate the effect of alcohol consumption on bone mineral density in males .Methods Association be-tween bone mineral density ,alkaline phosphatase and alcohol history ,daily alcohol consumption were analysed retrospectively in 563 men undergone physical examination .Results Of all the participates ,31 .6% has history of alcohol consumption for more than one year .The rate of osteopenia and osteoporosis was 31 .4% and 5 .9% ,respectively .The reduction of bone mineral density was posi-tively correlated with age ,length of alcohol consumption history ,daily alcohol consumption volume and the serum alkaline phospha-tase levels(P<0 .01) .The rate of osteopenia and osteoporosis were increased significantly in the males who had alcohol consump-tion history(P<0 .01) ,and paralleled with the increase of daily alcohol consumption (P<0 .01) .The alkaline phosphatase level of males with a history of alcohol consumption more than 20 years were higher than the ones without history of alcohol intake .While alkaline phosphatase level of the ones taking daily alcohol more than 50 g was higher than less than 50g or no consumption signifi-cantly(P<0 .05) .Conclusion Alcohol consumption is an important risk factor of male osteoporosis .%目的探讨乙醇摄入量对男性骨密度的影响。方法回顾性分析563例男性体检者乙醇摄入史和日摄入量与碱性磷酸酶（ALP）及骨密度的关联。结果563例男性体检者中，31．6％有1年以上乙醇摄入史，骨量减少和骨质疏松（OP）的发生率分别为31．4％和5．9％。骨密度降低与年龄、乙醇摄入史、日摄入量及ALP水平呈正相关（P＜0．01）。OP和骨量减少在有乙醇摄入史男性中发生率明显增加（P＜0．01），且随日摄入量的增加而增加（P＜0．01）。乙醇摄入史大于20年组与无乙醇摄入史组，日摄入量50～100g和大于100g组与0g组、小于50g组分别比较，ALP差异均有统计学意义（P＜0．05）。结论乙醇摄入是导致男性OP发生的重要原因。
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