Objective To investigate the clinical symptoms and diagnosis of ketamine-associated cystitis ,and evaluate the effec-tiveness of treatment .Methods From march 2008 to march 2013 ,21 cases of patients (16 males and 5 females)were respectively studied .And O′leary-sant scores and urodynamic index were taken to analysis .Results After comprehensive treatment of hydrodis-tention ,the O′leary-sant scores and frequency of unstable detrusor contraction were decreased ,and the maximum bladder capacity was expanded among 21 patients with average follow-up time of 8 ± 4 months .Conclusion Long-term ketamine abuse can cause se-vere lower urinary tract symptoms ,such as urinary frequency ,urgency and more severe cases of bladder contracture .However ,the hydrodistention can significantly increase bladder capacity under anesthesia with intravesical instillation .%目的：探讨氯胺酮相关性膀胱炎的临床表现、诊断及其治疗方法的有效性。方法回顾性地分析了2008年3月至2013年3月该院收治的氯胺酮相关性膀胱炎患者21例，其中男16例，女5例。采取O′Leary-Sant评分及其尿流动力学检查的方法对水扩张治疗前后疗效进行比较。结果经过水扩等综合治疗后，平均随访（8±4）个月，21例患者O′Leary-Sant症状和问题评分明显降低，膀胱容量增加，逼尿肌不稳定收缩频率减少。结论长期吸食氯胺酮可导致严重的下尿路症状，以尿频、尿急为主，严重者有膀胱挛缩。而麻醉状态下水扩张能显著地增加膀胱容量，配合膀胱灌注等综合治疗，可有效地治疗氯胺酮相关性膀胱炎。
展开▼
