目的 探讨高血压患者血清补体C3、超敏C反应蛋白(hs-CRP)水平变化与胰岛素抵抗(IR)指数(HOMA2-IR)的相关性.方法 选择2008～2010年重庆医科大学附属第一医院内分泌科年龄25～80岁的高血压患者139例,以HOMA2-IR上四分位为切点分为IR组与非IR组[HOMA2-IR≥1.47为IR组(n=35);HOMA2-IR＜1.47为非IR组(n=104)],观察两组患者补体C3、hs-CRP水平变化与HOMA2-IR的相关性.结果 IR组血清补体C3和hs-CRP水平显著高于非IR组.校正性别、年龄、BMI、腰围后,补体C3仍与HOMA2-IR正相关(P＜0.05).多元线性逐步回归分析表明,补体C3是HOMA2-IR的主要影响因素(P＜0.05).结论 在高血压人群中,补体C3独立于肥胖与HOMA2-IR相关,且相关性强于hs-CRP,补体C3可能是反应IR炎症状态更好的生物学指标.%Objective To observe the serum levels of complement component 3(C3) and high sensitive C reactive protein(hsCRP), and to compare their association with HOMA2-IR in hypertensive patients. Methods 139 hypertensive subjects were recruited. Weight, height, blood pressure, wasist circumference, fasting plasma glucose ( FPG), fasting serum insulin ( Fins), blood lipids,C3 and hs CRP were measared. HOMA index(HOMA2-IR) was calculated. Insulin resistance was defined as the upper quartile of HOMA2-IR. Results C3 and hs-CRP were significantly higher in subjects with IR compared with subjects without. After adjustment for gender, age, BMI, and waist circumference, C3 was still positively and significantly correlated with HOMA2-IR(P＜0.05). By regression analysis,C3 was the main influential factor of HOMA2-IR(P＜0.05)Moreover , compared with low C3 subjects,high C3 subjects were 3.54(P＜0.01)times more likely to be with IR. Conclusion Compared to hs-CRP, C3 has a stronger association with HOMA2-IR, independent of obesity;C3 might be a better inflammatory marker of insulin resistance in hypertensive subjects.
展开▼
