尿酸是嘌呤代谢的终末产物,血尿酸(SUA)增高影响动脉粥样斑块的稳定性,增加冠心病患者心肌梗死、心力衰竭的发生率和全因死亡率,尤其是女性患者冠心病的发病率显著增加.与正常血压青少年相比,SUA每增加1 mg/L,青少年高血压前期或高血压的患病风险增加50%,男性高于女性.高尿酸血症(HUA)增加糖耐量异常、糖尿病以及糖尿病肾病的患病风险.一定程度上加重胰岛素抵抗、肥胖、脂质代谢紊乱等代谢综合征表现.尽管HUA增加心血管疾病的患病率风险.但对于无症状HUA的治疗国内外专家尚有不同推荐建议.%Uric acid is the ending product of purine metabolism.Increased serum uric acid (SUA)affects the stability of atheromatous plaque and increases the incidence of myocardial infarction, heart failure and all-cause mortality of patients with coronary heart disease (CHD).Especially in female patients,the incidence of CHD has increased significantly. Using normotensive children for comparison, the risk of showing prehypertension or hypertension increases by at least 50% for each 1 mg/L SUA increase in adolescence.The morbidity of hypertention in male is higher than that in female.Hyperuricemia (HUA)also adds the risk of diabetes,abnormal glucose tolerance and diabetic nephropathy.To some extent, HUA aggravates symptoms of metabolic syndrome such as insulin resistance,obesity or lipid metabolic disorders.Although HUA increases prevalence risk of cardiovascular disease, there is no consensus recommendation for the treatment of asymptomatic HUA at home and abroad.
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