Objective To study the analysis of ultrasonic evaluation of drug intervention treatment of high blood pressure patients carotid artery elastic function changes.Methods Hypertension patients divided into two groups: drug intervention group (group A) and the intervention group (group B), healthy control group (group C).Drug intervention group (ordinary cloth combined aspirin and atorvastatin) oral profumo burqa 0.5 g, 2 times a day, 100 mg of aspirin, 1 x per day, atorvastatin 10 mg, 1 times a day, 12 weeks, and then use ultrasound detecting IMT , shrinkage end inner diameter and end-diastolic diameter , observe the IMT, IMT/Ds, PP , Ds and Dd and Ds-Dd.Results Hypertension before drug intervention group A and group B mIMT[ (1.2±0.2)mm,(1.2±0.3)mm], IMT/Ds [(13.7±2.0)%,(13.6±1.9)%]were significantly increased compared with healthy controls[(0.8±0.1) mm,(11.5±1.6)%] (P<0.01).After the drug intervention group APP, DS, Dd [(46.3±6.6),(7.1±0.9), (6.9±0.8)]is reduced, the DS - Dd(0.6±0.2)increased (P< 0.05).And not the drug intervention group B has no obvious change;Group A TC TG,LDL-C, hs - CRP, ox - LDL[(4.3±0.3),(1.3±0.2),(1.6±0.6) ,(2.6±0.6),(3.4±1.2),(4.4±1.1l)], and other indicators were significantly lower (P<0.05),and not the drug intervention group B has no obvious change. Conclusion Vascular ultrasound can quantitatively reflect the high blood pressure patients drug intervention treatment before and after the change of the function of blood vessel elasticity, carotid artery elastic function have independent predictive value for cardiovascular disease.%目的研究分析超声评价药物干预治疗高血压病患者颈动脉弹性功能变化情况。方法将126例高血压组患者分为2组：药物干预组62例（A组）和非干预组64例（B组），50位健康人为对照组（C组）。药物干预组采用普罗布考联合阿司匹林、阿托伐他汀治疗，口服普罗布考0.5g,2次/d，阿司匹林100 mg,1次/d，阿托伐他汀10 mg，1次/d，服用12周；非干预组不服用上述药物，其他降压等治疗措施均与干预组一致；然后用超声技术检测IMT、收缩末内径和舒张末内径，观察IMT、IMT/Ds、PP、DS、Dd以及DS-Dd的变化。结果药物干预前高血压A组、B组的mIMT[（1.2±0.2）mm、（1.2±0.3）mm]、IMT/Ds [（13.7±2.0）%、（13.6±1.9）%]均较健康对照组[（0.8±0.1）mm、（11.5±1.6）%]显著升高（P<0.01）。药物干预后A组的PP、DS、Dd[（46.3±6.6）、（7.1±0.9）、6.9±0.8）]降低，DS-Dd（0.6±0.2）增加（P＜0.05）。而B组未实施药物干预上述指标无明显变化；A组的TC、TG、LDL-C、hs-CRP、ox-LDL[（4.3±0.3）、（1.3±0.2）、（1.6±0.6）、（2.6±0.6）、（3.4±1.2）、（4.4±1.1）]等各项指标均显著降低（P<0.05），而B组未实施药物干预上述指标无明显变化。结论血管超声可以定量反映高血压病患者药物干预治疗前后血管弹性功能的变化，颈动脉弹性功能对心血管疾病具有独立的预测价值。
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