Objective: To investigate application effect of hydromorphone hydrochloride epidural preemptive analgesia combined with intravenous self-control analgesia after hip surgery. Methods:110 patients with hip surgery were selected in hospital from October 2013 to October 2015 were divided into two groups by random number table method. In control group, 55 patients treated conventionalspinal-epidural combined anesthesia, then gave physiological saline 5 ml from epidural tube, and receivedpostoperative intravenous self-control analgesia pump. Inobservation group, 55 patients treated conventionalspinal-epidural combined anesthesia, then gave hydromorphone hydrochloride 0.3 mg+physiological saline 5 ml from epidural tube, and receivedpostoperative intravenous self-control analgesia pump. Sedative effect, analgesic effect , adverse reactions were compared between two groups. Results:As time prolonged, sedation score and pain score decreased in two groups(P<0.05). Sedation score at postoperative 2 h, 6 h, 12 h, 24 h, 48 h in observation group were higher than control group(P<0.05). Pain scores were lower than control group(P<0.05). Sedative effect, analgesic effect in observation group were better than control group(P<0.05). Incidence of adverse reactions in observation group was lower than control group(P<0.05). Demand times of intravenous self-control analgesia pump, indwelling time of catheter in observation group were less than control group(P<0.05). Conclusion:Hydromorphone hydrochloride epidural preemptive analgesia combined with intravenous self-control analgesia have significant application effect after hip surgery, with better sedative effect and analgesic effect. And postoperative recovery is fast and safe.%目的：探讨盐酸氢吗啡酮硬膜外超前镇痛联合静脉自控镇痛在髋部术后的应用效果。方法：选取本院2013年10月—2015年10月择期行髋部手术患者110例，采用随机数字表法分为两组，对照组患者55例行常规腰硬联合麻醉后，从硬膜外管内给予生理盐水5mL，术后接静脉自控镇痛泵；观察组患者55例行常规腰硬联合麻醉后，从硬膜外管内给予盐酸氢吗啡酮0.3mg+生理盐水至5mL，术后接静脉自控镇痛泵。比较两组患者的镇静效果、镇痛效果及不良反应情况。结果：随时间延长，两组患者镇静评分、疼痛评分降低(P<0.05)。观察组患者术后2h、6h、12h、24h、48h时镇静评分高于对照组(P<0.05)同时疼痛评分低于对照组(P<0.05)。观察组患者镇静效果、镇痛效果优于对照组(P<0.05)。观察组患者不良反应发生率低于对照组(P<0.05)。观察组患者静脉自控镇痛泵按压次数、尿管留置时间少于对照组(P<0.05)。结论：盐酸氢吗啡酮硬膜外超前镇痛联合静脉自控镇痛在髋部术后的应用效果显著，具有良好镇痛、镇静效果，不良反应少，术后恢复快且安全性高。
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