This paper introduces the importance of main control room (MCR) in nuclear power plant, then analysis the principles and goals in designing. At last, the MCR design lfow based on human factor engineering is discussed and shows the reliability and safety.%本文主要阐述了核电站主控室室的重要性与发展要求，介绍了主控室的设计目标和设计思路进行，重点论述了以人因工程原则为指导的控制室的设计流程，结果表明依据人因工程理念设计的控制室能够具有较高的安全性和可靠性。
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