目的:评估双歧杆菌四联活菌对老年慢性功能性便秘的临床疗效.方法:选取确诊为慢性功能性便秘的老年患者175例,根据门诊号末尾数字分组,偶数者为观察组(91例),奇数者为对照组(84例).观察组患者采用双歧杆菌四联活菌治疗,对照组患者采用莫沙必利治疗,周期为28 d,比较两组患者便秘及伴随症状的改善情况.结果:治疗期间,两组患者的粪便性状及大便次数逐渐改善或恢复正常,治疗7 d后,观察组患者粪便性状、大便次数的治愈率明显高于对照组,差异均有统计学意义(P<0.05);治疗期间,两组患者腹痛、腹胀、排便困难及食欲减退等症状均明显缓解,治疗21 d后,观察组患者上述症状治愈率明显高于对照组,差异均有统计学意义(P<0.05).结论:双歧杆菌四联活菌可有效解决老年慢性功能性便秘患者腹痛、腹胀、排便困难及食欲减退等症状,疗效显著,安全可靠.%OBJECTIVE:To evaluate the clinical efficacy of Bifidobacterium tetravaccine tablets ( live) in treatment of chronic elderly constipation . METHODS: 175 elderly patients diagnosed chronic constipation were selected , according to the numbers at the end of outpatient number , even numbers were classified as observation group (91 cases), odd number was classified as control group ( 84 cases ).The observation group was treated with Bifidobacterium tetravaccine tablets ( live ) , while the control group was given mosapride , both groups received a treatment course of 28 days.The improvement of constipation and incidental symptoms between two groups was compared .RESULTS: During treatment , the fecal features and defecate frequency of both groups were gradually improved or returned to normal , 7 days after treatment , the fecal features and improvement rates defecate frequency of observation group were significantly higher than those of the control group , with statistically significant differences ( P<0.05 );during treatment , symptoms including abdominal pain , abdominal distention , difficult defecation and anorexia of both groups had been significantly relieved , 21 days after treatment , the cure rates of above symptoms of observation group were significantly higher than those of the control group , with statistically significant differences ( P<0.05 ) .CONCLUSIONS: The Bifidobacterium tetravaccine tablets ( live ) can effectively solve symptoms including abdominal pain , abdominal distention , difficult defecation and anorexia for elderly patients with chronic constipation , with remarkable efficacy and high safety .
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