OBJECTIVE: To probe into the efficacy of low molecular weight heparin ( LMWH ) combined with urokinase in treatment of acute myocardial infarction ( AMI) and its effects on patients'quality of life.METHODS:160 patients with AMI admitted into Qianjiang Central Hospital from Jan .2013 to Jan.2016 were selected and divided into observation group and control group via random number table , with 80 cases in each .Both groups were given conventional treatment , on this basis , the control group was treated with urokinase , while the observation group was given LMWH based on the control group .Clinical efficacy , recovery condition of coronary artery , scores of WHOQOL-BREF , scores of self-rating depression scale and self-rating anxiety scale of two groups were observed .RESULTS:The total effective rate of observation group ( 96.25％, 77/80 ) was significantly higher than that of the control group (85.00％, 68/80), with statistically significantly difference ( P<0.05); the recanalization rate of coronary artery observation group (93.75％, 75/80) was significantly higher than that of the control group (82.50％, 66/80), with statistically significantly difference ( P<0.05 ); after treatment , score of WHOQOL-BREF of observation group was significantly higher than that of the control group , scores of self-rating depression scale and self-rating anxiety scale of observation group were significantly lower than those of the control group , with statistically significantly differences (P<0.05).CONCLUSIONS:The efficacy of LMWH combined with urokinase in treatment of AMI is remarkable , which can significantly improve patients 'quality of life .%目的:探讨低分子肝素联合尿激酶治疗急性心肌梗死的疗效及对患者生活质量的影响.方法:选取2013年1月—2016年1月潜江市中心医院收治的急性心肌梗死患者160例作为研究对象,以随机数字表法分为观察组和对照组,每组80例.两组患者均给予常规治疗,在此基础上,对照组患者给予尿激酶治疗,观察组患者在对照组的基础上加用低分子肝素治疗.观察两组患者的临床疗效、冠状动脉恢复情况、生活质量测定量表评分、抑郁自评量表评分及焦虑自评量表评分.结果:观察组患者的总有效率为96.25％(77/80),明显高于对照组的85.00％(68/80),差异有统计学意义(P<0.05);观察组患者冠状动脉再通率为93.75％(75/80),明显高于对照组的82.50％(66/80),差异有统计学意义(P<0.05);治疗后,观察组患者生活质量测定量表评分明显高于对照组,抑郁自评量表评分及焦虑自评量表评分明显低于对照组,差异均有统计学意义(P<0.05).结论:低分子肝素联合尿激酶治疗急性心肌梗死的疗效显著,可改善患者生活质量.
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