Objective:To probe into the efficacy of seven groups of antibiotics in treatment of bronchiectasis complicated with infections,so as to screen out the therapeutic regimen with significant efficacy and low costs.METHODS: 111 patients with bronchiectasis complicated with infections admitted into People's Hospital of Xuancheng from Jul.2014 to Dec.2015 were selected to be divided into group A(amoxicillin potassium clavulanate+levofloxacin)with 15 cases,group B(amoxicillin potassium clavulanate+azithromycin)with 15 cases,group C(cefminox+amikacin)with 15 cases,group D(cefoperazone sulbactam+amikacin)with 17 cases,group E(cefoperazone sulbactam+levofloxacin)with 19 cases,group F(ceftazidime+amikacin)with 15 cases and group G(ceftazidime+levofloxacin)with 15 cases via the random number table.The clinical efficacy,length of hospital,antibiotics costs and incidence of adverse drug reactions of seven groups were observed.RESULTS: The total effective rates of group D,E,F,G were all >90％,and there was no statistical significance among four groups(P>0.05).Except for invalid cases,there was no statistical significance among seven groups(P>0.05).The antibiotics costs of group D were the lowest,followed by group F,there was no statistical significance between group D and F(P>0.05).The incidences of adverse drug reactions in group C,D and F were the lowest,compared with other groups,the difference was statistically significant(P90％,且该四组患者总有效率的差异无统计学意义(P> 0.05).排除无效病例后,组间比较,七组患者住院时间的差异无统计学意义(P>0.05).D组患者抗菌药物费用最低,其次为F组,D、F组患者抗菌药物费用的差异无统计学意义(P>0.05).C、D、F组患者不良反应发生率最低,与其他各组比较,差异均有统计学意义(P<0.05).结论:头孢他啶联合阿米卡星治疗支气管扩张合并感染的疗效最好、住院时间最短、抗菌药物费用较低、住院总费用最低、不良反应最少.
展开▼
