目的:了解盐城市第一人民医院(以下简称"我院")严重的药品不良反应(adverse drug reaction,ADR)发生的特点.方法:对我院2011年1月-2016年12月收集到的56例严重的ADR报告进行分析.结果:56例严重的ADR报告中,女性患者略多于男性,男女比例为1:1.07;>40岁病例数最多(49例,占87.50％);静脉滴注引发的ADR病例数最多(45例,占80.36％);抗菌药物引发的严重的ADR病例数最多(20例,占34.48％),其次为中药制剂(10例,占17.24％);严重的ADR累及器官和(或)系统以中枢神经系统最为多见,其次为皮肤及其附件,再次为呼吸系统、全身性.给予对症处理后,大部分患者痊愈或好转.结论:应加强对严重的ADR的监护,减少和避免严重的ADR发生,促进临床合理用药.%Objective:To investigate the characteristics of severe adverse drug reactions(ADR)in Yancheng the First People's Hospital(hereinafter referred to as "our hospital).METHODS: 56 cases of severe ADR reports in our hospital from Jan.2011 to Dec.2016 were analyzed.RESULTS: Among the 56 cases of severe ADR,the number of male patients was slightly more than female,with the ratio of 1∶1.07,and most patients aged over 40(49 cases,87.50％).Intravenous drip was the primary cause of ADR(45 cases,80.36％).Most severe ADR were caused by antibacterial drugs(20 cases,34.48％),the next was traditional Chinese medicine(10 cases,17.24％).The main organs and(or)systems involved by severe ADR were respectively central nervous system,skin and its accessories,systemic damage and respiratory system.All patients got better or cured after drug withdrawal in time or expectant treatment.CONSLUSIONS: Monitoring on severe ADR needs to be reinforced to reduce or avoid,so as to improve clinical rational drug application.
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