OBJECTIVE:To probe into the efficacy and safety of clopidogrel combined with aspirin in treatment of unstable angina pectoris .METHODS:110 patients with unstable angina pectoris admitted into Kaifeng Central Hospital from Mar.2015 to Jun.2017 were selected and divided into observation group and control group via random number table, with 55 cases in each .The control group was treated with aspirin , while the observation group was given clopidogrel combined with aspirin .Differences of frequency and duration of angina pectoris before and after treatment , clinical efficacy , and incidences of adverse drug reactions between two groups were compared .RESULTS: After treatment, the frequency and duration of angina pectoris of observation group were significantly lower than those of control group, with statistically significant difference ( P <0.05 ); the total effective rate of observation group (94.55％, 52/55 ) was significantly higher than that of the control group ( 69.09％, 38/55 ) , with statistically significant difference (P<0.05);the incidence of adverse drug reactions of observation group (5.45％, 3/55) was significantly lower than that of the control group ( 18.18％, 10/55 ) , with statistically significant difference ( P <0.05).CONCLUSIONS:The efficacy of clopidogrel combined with aspirin in treatment of unstable angina pectoris is remarkable , with high safety .%目的:探讨氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效与安全性.方法:选取2015年3月—2017年6月开封市中心医院收治的不稳定型心绞痛患者110例作为研究对象,以随机数字表法分为观察组和对照组,每组55例.对照组患者给予阿司匹林,观察组患者在对照组的基础上加用氯吡格雷.比较两组患者治疗前后心绞痛发作频率和持续时间、临床疗效及不良反应发生情况.结果:治疗后,观察组患者心绞痛发作频率和持续时间明显低于对照组,差异均有统计学意义(P<0.05);观察组患者的总有效率为94.55％(52/55),明显高于对照组的69.09％(38/55),差异有统计学意义(P<0.05);观察组患者不良反应发生率为5.45％(3/55),明显低于对照组的18.18％(10/55),差异有统计学意义(P<0.05).结论:氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效显著,安全性较高.
展开▼
