OBJECTIVE:To probe into the clinical efficacy of two regimens of trigeminy medication in treatment of bronchiolitis in chidren , and to evaluate the medical efficiency , so as to provide references for rational drug application .METHODS:Retrospective analysis was adopted , 126 children with bronchiolitis were divided into control group(61 cases) and observation group (65 cases) according to different therapeutic regimens .The control group was given nebulizer therapy of budesonide combined with terbutaline and 3％ sodium chloride solution , while the observation group was given nebulizer therapy of budesonide combined with salbutamol and 3％ sodium chloride solution .Clinical symptoms , improvements of physical signs and incidences of adverse drug reactions of two groups were observed , the costs and cost-effectiveness ratios of both therapeutic regimens were calculated .RESULTS: The total effective rates of control group and observation group were respectively 98.36％(60/61) and 96.92％(63/65), the difference had no statistical significance ( P>0.05 );the cost-effectiveness ratios of control group and observation group were respectively 445.79 and 619.25;during medication , no adverse drug reactions appeared in control group , 2 cases of aggravated cough appeared in observation group , no severe adverse drug reactions were found in both groups .CONCLUSIONS:In consideration of pharmacotherapeutics , pharmacoeconomics and drug safety , the nebulizer therapy of budesonide combined with salbutamol and 3％ sodium chloride solution is better than the combination of budesonide , terbutaline and 3％sodium chloride solution%目的:探讨两种三联方案治疗小儿毛细支气管炎的临床疗效,评价其经济性,为合理用药提供参考.方法:采用回顾性研究方法,根据治疗方案的不同,将126例毛细支气管炎患儿分为对照组(61例)和观察组(65例).对照组患儿采用布地奈德、特布他林及3％氯化钠溶液雾化治疗,观察组患儿采用布地奈德、沙丁胺醇及3％氯化钠溶液雾化治疗.观察两组患儿的临床症状、体征改善情况及不良反应发生情况,计算两组治疗方案的成本及成本-效果比.结果:对照组、观察组患儿治疗总有效率分别为98.36％(60/61)、96.92％(63/65),两组的差异无统计学意义(P<0.05);对照组、观察组治疗方案的成本-效果比分别为445.79、619.25;用药期间,对照组患儿未发生不良反应,观察组2例患儿发生咳嗽加剧,两组患儿均未发生严重不良反应.结论:结合药物治疗学、药物经济学及药物安全性而言,对于小儿毛细支气管炎,布地奈德、特布他林及3％氯化钠溶液雾化治疗方案优于布地奈德、沙丁胺醇及3％氯化钠溶液雾化治疗方案.
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