目的：探讨长期服用小剂量阿司匹林引发不良反应（ adverse drug reaction ，ADR）的特点及影响因素。方法：收集滨州市中心医院（以下简称“我院”）2013年1月—2014年6月门诊和住院患者，筛选出医师、药师和护士呈报的阿司匹林ADR报告共103例。结果：小剂量阿司匹林致ADR老年患者居多（占56.31％），且男性（占61.17％）多于女性；原患疾病主要为各类心脑血管疾病；联合用药主要为阿司匹林与硫酸氢氯吡格雷片联用；临床表现以消化系统、血液系统损害为主，分别为84例（占81.55％）和5例（占4.85％）。经治疗后大多数患者好转，部分痊愈。结论：临床应高度重视阿司匹林引起的ADR，尤其是消化道出血等严重ADR，每位临床医师都应参考《中国心血管病预防指南》，在用药之前对患者进行风险评估，以确保患者安全用药。%OBJECTIVE:To explore the characteristics and related factors of adverse drug reactions ( ADR ) induced by long-term low-dose aspirin .METHODS: 103 cases of ADR reports induced by low-dose aspirin from outpatient and inpatient department of Binzhou Central Hospital ( hereinafter referred to as “our hospital”) from Jan. 2013 to Jun .2014 were screened by the physician , pharmacist and nurse .RESULTS:ADR cases induced by low-dose aspirin mostly occurred in the elderly (56.31%), and more males(61.17%)than females.Primary diseases mainly occurred in all types of cardiovascular and cerebrovascular diseases .The drug combination were mainly aspirin and Clopidogrel hydrogen sulfate tablets .The main clinical manifestations were digestive system , blood system damage , respectively 84 cases(81.55%)and 5 cases(4.85%).Most cases were likely to get better after treatment , some had already recovered .CONCLUSIONS:The clinic should attach more importance to ADR induced by aspirin , especially the serious ADR like the gastrointestinal bleeding .Every clinician should refer to Guide for Chinese Cardiovascular Disease Prevention , and evaluate the risk before administration , so as to ensure the security of medication .
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