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首页> 外文学位 >Negative Affect and Resumption Of Drug Use: Neurobiology of Enhanced Dysphoria and Subsequent Drug Taking Following Prolonged Abstinence from Cocaine
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Negative Affect and Resumption Of Drug Use: Neurobiology of Enhanced Dysphoria and Subsequent Drug Taking Following Prolonged Abstinence from Cocaine

机译：负面影响和恢复吸毒：可卡因的长期禁欲后增强的烦躁和随后服用药物的神经生物学

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摘要

Rats exhibit negative affect to a sweet tastant that predicts delayed cocaine availability, and nucleus accumbens (NAc) neurons encode this state. Here, we examined the effects of cocaine abstinence on negative affect and drug-seeking. Rats were given 14 taste-cocaine sessions followed by 1 or 30 days of abstinence and a 3-phase test: 1) tastant deliveries, 2) extinction, 3) cocaine self-administration, with NAc activity and affective responses to the taste measured on days 1, 14 and test. Results showed that 30 days of abstinence led to an enhancement of negative affect and a decline in NAc activity during tastant infusion that re-emerged during drug-seeking. Further, greater aversion to the drug-paired tastant before abstinence was associated with increased self-administration following 30-day abstinence. These findings show that drug-induced dysphoria is enhanced following prolonged cocaine abstinence, and that NAc encoding is dynamic, dampening as negative affect is enhanced, but re-engaging during drug-seeking and taking.
机译：大鼠对甜味剂表现出负面影响，这种甜味剂预测可卡因的延迟供应，伏伏核（NAc）神经元编码这种状态。在这里，我们检查了可卡因节制对负面影响和寻求毒品的影响。给予大鼠14次可卡因味觉治疗，然后禁欲1或30天，并进行3期试验：1）释放味觉，2）灭绝，3）可卡因自我给药，NAc活性和对味觉的情感反应第1、14天并测试。结果显示，禁酒30天导致在寻求药物期间重新出现的味觉注入过程中负面影响增强和NAc活性下降。此外，禁食前对药物配对的促味剂的厌恶程度较大，与禁食30天后的自我给药增加有关。这些发现表明，长期禁止可卡因后，药物诱发的烦躁情绪会增强，并且NAc编码是动态的，随着负面影响的增强而减弱，但在寻药和服用过程中重新参与。

著录项

  • 作者

    Haake, Rachel McDonnell.;

  • 作者单位

    The University of North Carolina at Chapel Hill.;

  • 授予单位 The University of North Carolina at Chapel Hill.;
  • 学科 Psychobiology.
  • 学位 M.A.
  • 年度 2017
  • 页码 49 p.
  • 总页数 49
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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