OBJECTIVE:To probe into the causes , mechanism and preventive measures of drug-induced liver damage by traditional Chinese medicine .METHODS:40 cases diagnosed with drug-induced liver damage admitted into Affiliated Hospital of Changchun University of Traditional Chinese Medicine ( hereinafter referred to as “our hospital”) from Jan.2014 to Dec.2015 were extracted as the research objects , retrospective analysis was conducted on the clinical data.RESULTS:The ratio of patients with drug-induced liver damage for 3 d-2 w was 35%(14/40), for >2-4 w was 55%( 22/40 ) , for 2-3 months was 10%( 4/40 ); the ratio of oral Chinese patent medicine was 40%( 16/40 ) , and decoction was 30%( 12/40 ); the ratio of traditional Chinese medicine injection was 20%( 8/40 ) , and external treatment was 10%(4/40).CONCLUSIONS:Various traditional Chinese medicine can induce drug-induced liver damage , among which plant medicine take the lead .It is necessary to require traditional Chinese pharmacists to comprehensively understand the traditional Chinese medicine characteristics of drug-induced liver damage , strengthen the consciousness of safe medication , closely observe the reactions during administration and monitor the liver function , so as to ensure the treatment safety for patients .%目的：探讨中药导致药源性肝损害的原因、机制和预防措施。方法：从长春中医药大学附属医院（以下简称“我院”）2014年1月—2015月12月诊治的药源性肝损害患者中抽取40例作研究对象，回顾性分析其临床资料。结果：患者发生药源性肝损害的时间方面，用药3 d～2周者占35％（14／40），＞2～4周者占55％（22／40），2～3个月者占10％（4／40）；中成药口服剂占40％（16／40），中草药汤剂占30％（12／40），中药注射剂占20％（8／40），中草药外敷占10％（4／40）。结论：可导致药源性肝损害的中药较多，以植物药为主，应要求中药师全面了解可导致药源性肝损害反应的中药特性，增强安全用药意识，做到合理用药，严密观察患者用药期间的反应，予以肝功能监测，以保障患者治疗安全。
展开▼
