目的：了解60例口服抗糖尿病药致药品不良反应（adverse drug reaction，ADR）发生情况及特点，为临床合理用药提供参考。方法：收集2012年6月—2015年12月东莞常安医院上报60例相关ADR，对患者的年龄、原发疾病、累及器官和（或）系统、给药时间、涉及药物种类等进行统计分析。结果：60例ADR患者中，年龄＞56岁者的发生率为63.33％（38／60），45～≤56岁者为36.67％（22／60）；18例（30.00％）糖尿病伴高血压病患者出现ADR，然后依次为糖尿病性神经病变16例（26.67％）、慢性肾功能不全15例（25.00％）、糖尿病性血管性疾病11例（18.33％）；ADR主要累及器官和（或）系统以神经系统最为常见（25例，占41.67％）；ADR发生时间以用药1～7 d最多（39例，占65.00％）；引起ADR最多的药物为双胍类（29例，48.33％）。结论：抗糖尿病药致ADR的发生与多种因素有关，临床应加强ADR的监测，及早发现ADR，及早处理，促进临床合理用药。%OBJECTIVE:To investigate the occurrence characteristics of 60 cases of adverse drug reactions ( ADR) induced by oral antidiabetic drugs , so as to provide reference for the rational drug use in clinic .METHODS:Statistical analysis was conducted on 60 cases of ADR reports reported by Dongguan Chuang'an Hospital from Jun .2012 to Dec . 2015 in terms of patients'age, primary disease, ADR involved organs and (or) systems, administration time and included drug categories , etc..RESULTS: Of the 60 cases, the incidence of ADR in patients >56 years old was 63.33%(38/60),and patients 45-≤56 years old was 36.67% (22/60).There were 18 patients(30.00%) with hypertension complicated with diabetes mellitus had ADR , followed by 16 patients ( 26.67%) with diabetic neuropathies, 15 patients(25.00%) with chronic renal insufficiency , 11 patients (18.33%) with diabetic vascular disease.ADR mainly involved organs and (or) systems as nervous system(25 cases, 41.67%), the occurrence time of ADR were mainly 1-7 d ( 39 cases, 65.00%).And ADR induced by biguanides took the lead ( 29 cases, 48.33%) .CONCLUSIONS: The occurrence of ADR induced by oral antidiabetic drugs are associated with various factors, the clinic should strengthen the monitoring of ADR and timely find out ADR , so as to take some effective measures and promote the rational drug use in clinic .
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