目的：探讨右美托咪定对七氟烷麻醉下不停跳冠状动脉旁路移植术患者血流动力学的影响。方法：选取2013年10月—2014年11月郑州市中医院收治的行不停跳冠状动脉旁路移植术的患者112例，以随机数字表法分为观察组和对照组各56例。对照组给予0.9％氯化钠注射液，观察组给予右美托咪定。观察2组患者桡动脉穿刺完毕（T0）、气管插管完毕（T1）、劈开胸骨（ T2）、搭前降支（ T3）、头低位搭后降支（ T4）、术毕（ T5）时各项指标情况。结果：观察组患者在T1、T2、T4、T5时的平均动脉压均明显低于对照组，差异均有统计学意义（P＜0.05）；观察组患者在T1、T2、T4、T5时的心率均明显低于对照组，差异均有统计学意义（ P＜0.05）。结论：在七氟烷麻醉下不停跳冠状动脉旁路移植术中持续泵注右美托咪定，疗效较好，应激反应减轻，平均动脉压降低，改善心率，值得推广。%OBJECTIVE:To probe into the effects of dexmedetomidine on hemodynamics in patients with coronary artery bypass grafting under sevoflurane anesthesia .METHODS:112 patients with coronary artery bypass grafting admitted into Zhengzhou Traditional Chinese Medicine Hospital from Oct .2013 to Nov.2014 were selected to be divided into observation group and control group via the random number table , with 56 cases in each.The control group were treated with sodium chloride injections , while the observation group received dexmedetomidine .Various indicators at radial artery puncture (T0),tracheal intubation (T1),split sternum (T2),descending branch (T3),head down after the lower support (T4),after operation ( T5 ) in two groups were observed .RESULTS:The mean arterial pressure of observation group in T1 , T2 , T4 and T5 were significantly lower than that of control group , with statistically significant difference ( P<0.05) .And the heart rate of observation group in T1 , T2 , T4 and T5 were significantly lower than that of control group , with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of dexmedetomidine in continuous infusion in coronary artery bypass grafting under sevoflurane anesthesia is remarkable , with few stress responses , which can reduce the mean arterial pressure , improve the heart rate .It is worthy of application and promotion .
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