OBJECTIVE:To probe into the clinical efficacy and safety of sodium valproate combined with levetiracetam in treatment of children with epilepsy .METHODS:82 children with epilepsy admitted from Feb .2014 to Feb.2015 were selected to be divided into observation group and control group via the random number table , with 41 cases in each.The control group were treated with sodium valproate combined with topiramate , while the observation group received sodium valproate combined with levetiracetam .The efficacy , relevant laboratory indicators and adverse drug reactions of two groups were observed .RESULTS: After treatment, the total effective rate of observation group was 95.12%( 39/41 ) , significantly higher than that of control group [ 80.49%( 33/41 ) ] , with statistically significant difference ( P <0.05 ) .Compared with before treatment , the levels of blood calcium and phosphorus after treatment significantly decreased , the improvement of various indicators in observation group were better than that in control group , with statistically significant difference (P<0.05).There was no severe adverse drug reactions occurred in two groups .CONCLUSIONS: The efficacy of sodium valproate combined with levetiracetam in treatment of children with epilepsy is remarkable , which can improve the symptoms in children with epilepsy with high safety .Thus it has good application value in clinic .%目的：探讨丙戊酸钠联合左乙拉西坦小儿癫痫的疗效及安全性。方法：选取2014年2月—2015年2月收治的82例癫痫患儿，按随机数字表法分为对照组41例和观察组41例。对照组患儿给予丙戊酸钠联合托吡酯，观察组患儿给予丙戊酸钠联合左乙拉西坦，观察2组患儿的疗效、相关实验室指标及不良反应发生情况。结果：治疗后，观察组患儿的总有效率为95.12％（39／41），明显高于对照组的80.49％（33／41），差异有统计学意义（P＜0.05）；2组患儿血钙、血磷水平均较治疗前降低，且观察组改善情况优于对照组，差异有统计学意义（ P＜0.05）；2组患儿均未见严重不良反应发生。结论：丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效显著，可明显改善患儿症状，安全性较高，在临床中具有良好的应用价值。
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