目的：探讨服用伐尼克兰戒烟的疗效及其相关影响因素。方法：选择中山市人民医院2010年8月—2015年8月戒烟门诊应用伐尼克兰的141例患者，定期电话回访用药反应及戒烟情况。结果：服用伐尼克兰≤2周者7 d持续戒烟率为47.8％（45／94），服用2～4周者为40.7％（11／27），取药未服者为33.3％（6／20）；每日吸烟20支以下者的7 d持续戒烟率为51.5％（51／99），吸烟20～40支者为25.7％（9／35），吸烟大于40支者为28.6％（2／7）；用药3个月后，服药≤2周者药物戒烟成功率明显高于取药未服及服药2～4周者，差异有统计学差异（P＜0.05）。121例患者服药患者中，不良反应发生率为14.9％（18／121），1年复吸率为52.9％（64／121）。结论：伐尼克兰的戒烟效果较好，戒烟效果与服药时间、吸烟数量等相关。%OBJECTIVE:To probe into the efficacy of varenicline and related influencing factors on smoking cessation.METHODS:141 patients with varenicline admitted into Zhongshan People's Hospital from Aug.2010 to Aug.2015 were selected, the drug reactions and smoking cessation were observed by the phone visit.RESULTS:The 7 d continuous abstinence rate of patients with varenicline ≤2 weeks was 47.8%(45/94), patients with varenicline for 2-4 weeks was 40.7% ( 11/27 ) , and patients without taking drugs was 33.3% ( 6/20 ) .The 7 d continuous abstinence rate of patients with smoking number under 20 was 51.5%( 51/99 ) , patients with smoking number of 20-40 was 25.7%( 9/35 ) , and patients with smoking number over 40 was 28.6%( 2/7 ) .After administration of 3 months, the success rate of smoking of patients with varenicline≤2 weeks was higher than those of patients without taking drugs and patients with varenicline for 2-4 weeks, the difference was statistically significant( P<0.05) .Of the 121 patients with varenicline, the incidence of adverse drug reactions was 14.9%(18/121) , the relapse rate in 1 year was 52.9%( 64/121 ) .CONCLUSIONS: The efficacy of varenicline on smoking cessation is significant, which is closely related to the administration duration and number of smoking.
展开▼
