OBJECTIVE:To probe into the clinical efficacy of carbetoxin injection and oxytocin injection in prevention of hemorrhage after cesarean delivery under combined spinal epidural anesthesia.METHODS:200 patients after cesarean delivery under combined spinal epidural anesthesia admitted into the Second Affiliated Hospital of Mudanjiang Medical University from Mar.2014 to Mar.2016 were selected to be divided into observation group and control group via the random number table, with 100 cases in each.The observation group were treated with 100 μg carbetoxin, which was pushed slowly within 1 min; the invalid patients without any repeated drug use, and then oxytocin or card column element tromethamine were given.The control group received 10 U oxytoxin , with intravenous drip of oxytoxin injections 10 U+0.9%sodium chloride solution 500 ml, with speed of 100-150 ml/h.The effects of postpartum bleeding were compared between two groups. RESULTS: After treatment, the bleeding volume of observation group intraoperative, postoperative 2 h and 24 h was less than that of control group;the drop height of uterus in observation group postoperative 1 d and 3 d was larger than that in control group;the Hb and FIB of observation group were lower than those of before surgery;the ascent range of HR in observation group was lower than that of control group, with statistically significant difference( P<0.05) .CONCLUSIONS:The treatment of carbetoxin injection in prevention of hemorrhage, maintaining time and route of administration is better than that of traditional oxytocin injection.It is worth widely application in clinical treatment.%目的：比较卡贝缩宫素注射液与缩宫素注射液预防腰硬联合麻醉下剖宫产术后出血的临床效果。方法：选取2014年3月—2016年3月牡丹江医学院第二附属医院收治的经腰硬联合麻醉下的剖宫产患者200例作为研究对象，以随机数字表法分为观察组和对照组各100例。观察组患者在腰硬联合麻醉下行剖宫产术胎儿娩出后，缓慢静脉注射卡贝缩宫素注射液100μg，在1 min内完成，无效患者不重复给药，改用缩宫素注射液或卡前列素氨丁三醇等治疗。对照组患者在腰硬联合麻醉下行剖宫产术胎儿娩出后，子宫壁注射缩宫素注射液10 U，静脉滴注缩宫素注射液10 U＋0.9％氯化钠注射液500 ml，滴速为100～150 ml／h。比较2组患者产后止血效果。结果：治疗后，观察组患者术中及术后2、24 h出血量均明显小于对照组，术后1、3 d子宫下降高度均明显大于对照组，血红蛋白和血浆纤维蛋白原水平均明显低于术前，心率升高幅度明显低于对照组，差异均有统计学意义（ P＜0.05）。结论：卡贝缩宫素注射液用于预防腰硬联合麻醉下剖宫产术，在出血效果、维持时间、给药方式方面均优于传统单纯缩宫素治疗。
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