OBJECTIVE:To investigate the application of antibiotics in 540 non-surgical patients in Affiliated Hospital of Nantong University ( hereinafter referred to as “our hospital”) .METHODS: 20 non-surgical medical records each were monthly extracted, among which 15 were collected, and analysis was conducted on the application of antibiotics.RESULTS:540 medical records were analyzed during 3 years, including 26 departments and 25 kinds of antibiotics;and cephalosporins antibiotics took the lead, Antibiotics ranked by frequency of usage were respectively cefotaxime sodium, piperacillin and tazobactam sodium, latamoxef sodium, cefoperazone and tazobactam sodium, etc..Of the 225 patients with antibiotics, the number of cases with single medication took the lead, accounting for 69.33%(156/225) , and 63 cases were two-drug combination, 6 were three-drug combination.CONCLUSIONS:The application of antibiotics in our hospital accords with the standard, yet still has some problems.It is necessary to strengthen the training for clinical medical staff about the rational application of antibiotics and some other aspects and strengthen the inspection of the pathogen, so as to promote the rational application of antibiotics and prevent and delay the producing of clinical drug resistant bacteria.%目的：了解南通大学附属医院（以下简称“我院”）540例非手术患者抗菌药物应用情况。方法：每月随机抽取20份非手术出院患者病历，收集其中15份，对抗菌药物使用情况进行分析。结果：3年间分析540份病例，共涉及26个科室；抗菌药物共涉及25个品种，以头孢菌素类抗菌药物为主，使用频次由高到低依次为头孢噻肟钠舒巴坦钠、哌拉西林钠他唑巴坦钠、拉氧头孢钠、头孢哌酮钠他唑巴坦钠等；225例使用抗菌药物的病例中，单一用药的病例数最多，占69.33％（156／225），63例为2种药物联合使用，6例为3种药物联合应用。结论：我院抗菌药物的使用基本符合规定，但仍存在一定问题，应加强对临床医务人员有关抗菌药物合理应用等方面的培训，同时加强病原菌检查工作，以促进抗菌药物合理应用，防止和延缓临床耐药菌的产生。
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