目的：探讨骨科Ⅰ类切口手术围术期预防性应用抗菌药物的管理效果及临床药师在管理中的积极作用。方法：临床药师参与骨科Ⅰ类切口手术围术期预防性应用抗菌药物的管理工作。分别调取干预前、第1阶段干预后、第2阶段干预后骨科Ⅰ类切口手术患者的病历资料，对用药进行合理性评价，并对抗菌药物的预防性应用情况进行对比分析。结果：与干预前比较，第2阶段干预后骨科Ⅰ类切口手术围术期抗菌药物预防性使用率由98.56％下降至28.95％，降幅达70.63％；第2阶段干预后抗菌药物使用强度由96.31 DDDs／（100人· d）降至32.18 DDDs／（100人· d），降幅达66.59％；抗菌药物的品种选择、给药时间、用药疗程等均趋于合理。结论：临床药师参与Ⅰ类切口手术围术期预防性应用抗菌药物的管理工作，可有效规范抗菌药物的临床应用，提高用药合理性。%OBJECTIVE:To evaluate the intervention outcome on prophylactic use of antibiotics for orthopedic patients undergoing typeⅠincision surgery and the role of clinical pharmacists in the management of prophylactic use of antibiotics .METHODS:Clinical pharmacists were involved in the management of on prophylactic use of antibiotics for orthopedic patients undergoing typeⅠincision surgery .The medical records of the orthopedic patients undergoing type Ⅰincision surgery were reviewed before and after intervention ( first and second stage of intervention ) for evaluation of the rationality of the antibiotic use and comparative analysis regarding the prophylactic antibiotic use .RESULTS:Compared with pre-intervention ,usage rate of antibiotis dropped from 98.56%to 28.96%after second stage intervention ,decreasing by 70.63%; AUD declined from 96.31 DDDs/( 100 persons· day ) to 32.18 DDDs/( 100 persons· day ) , decreasing by 66.59%.The choice of varieties , delivering timing and duration of antibiotics were rational .CONCLUSIONS: The involvement of clinical pharmacists in the management of prophylactic use of antibiotics for orthopedic patients undergoing typeⅠincision operation effectively contributed to standardization and rational use of antibiotics .
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