目的：探讨联合应用支气管扩张剂治疗慢性阻塞性肺疾病（ chronic obstructive pulmonary disease，COPD）合并呼吸衰竭的临床效果。方法：将126例COPD合并呼吸衰竭患者以数字随机表法分为2组各63例，对照组患者给予噻托溴铵与盐酸氨溴索吸入治疗，观察组患者在对照组的基础上辅以沙丁胺醇吸入治疗，对比观察2组患者的临床疗效。结果：观察组患者的有效率为92．06％（58／63），明显高于对照组的79．37％（50／63），差异有统计学意义（P＜0．05）；治疗后，观察组患者的氧分压、一秒用力呼气容积及其占预计值百分比均明显高于对照组，二氧化碳分压明显低于对照组，差异均有统计学意义（ P＜0．05）。结论：联合应用支气管扩张剂治疗COPD合并呼吸衰竭，能纠正呼吸衰竭，改善肺功能。%OBJECTIVE:To evluate the clinical effiacy of combined bronchodilator therapy in treating patients with chronic obstructive pulmonary disease(COPD)complicated by respiratory failure.METHODS:126 cases of COPD patients with respiratory failure were randomized to two groups of 63 cases each, and were treated with tiotropium bromide plus ambroxol hydrochloride inhalation alone(control group)or in combination with salbutamol inhalation(treatment group)The clinical efficacy of the two groups of patients were followed and evaluated.RESULTS: The total effective rate in the observation group was significantly higher than in the control group[92.06%(58/63)vs.79.37%(50/63)](P<0.05);after treatment, the PaO2 , FEV1 and FEV1%were significantly higher while PaCO2 was significantly lower in the observation group than in the control group(P<0.05).CONCLUSIONS:Combined use of bronchodilators can correct respiratory failure and improve pulmonary function in patients with COPD associated with respiratory failure.
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