OBJECTIVE:To probe into the clinic efficacy and safety of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence. METHODS: 100 cases in Xinrongqi Hospital of Foshan Shunde Distinct from Jun. 2012 to Oct. 2015 were selected to be divided into the control group and observation group according to the random number table, with 50 cases in each group. The observation group received estradiol and midodrine hydrochloride in vaginal, the experimental group underwent TVT operation therapy. The clinic efficacy and self evaluation, the urine flow dynamic index before and after treatment, the adverse reactions, the improvement time of median average urinary incontinence and hospitalization costs and some other indexes were observed in two groups. RESULTS:After treatment, volume of urinary incontinence and self evaluation score in two groups both had an obvious improvement compared with before treatment, and the improvement in observation group was better than that in control group, with significant difference(P<0. 05);the urine flow dynamic index also had been improved a lot in two groups, various indexes in the observation group were higher than that in the control group, with significant difference ( P <0. 05 ) . Rate of adverse reaction in observation group was 2. 00%(1/50),which was significantly lower than that in control group 30%(15/50), with significant difference(P <0. 05) . The improvement time of average urinary incontinence in observation group was ( 6. 45 ± 2. 23 ) , which was significantly shorter than that in control group ( 8. 76 ± 3. 21 ) , with significant difference ( P<0. 05 ) . Hospitalization costs in observation group was ( 4 544. 56 ± 543. 45 ) , which was significantly lower than those in control group (6 566. 38 ±432. 23), with significant difference(P<0. 05). CONCLUSIONS: The clinic efficacy of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence is safe and effective, with fewer adverse reactions. The method can lighten the economic burden of the patients, and it is worthy of further clinical promotion and application.%目的:探讨阴道内应用雌二醇、盐酸米多君治疗轻、中度压力性尿失禁的临床效果和安全性. 方法:选取顺德区新容奇医院2012年6月-2015年5月间收治的患者100例,按随机数字表法分为观察组和对照组各50例. 观察组患者行雌二醇和盐酸米多君阴道给药,对照组患者行TVT手术治疗,观察2组患者的临床疗效与自我评价、治疗前后的尿流动力学指标、不良反应、中位平均遗尿的改善时间与住院费用等指标. 结果:治疗后,2组患者尿失禁量、自我等级评分均较治疗前有明显改善,且观察组改善情况明显优于对照组,差异均有统计学意义(P<0. 05);2组患者各尿流动力学指标均较治疗前有明显改善,且观察组各指标改善情况明显优于对照组,差异有统计学意义( P<0. 05 );观察组患者不良反应率为2. 00%( 1/50 ) ,明显低于于对照组的30%(15/50),差异有统计学意义(P<0. 05);观察组患者平均遗尿改善时间为(6. 45 ± 2. 23)个月,明显短于对照组的(8. 76 ± 3. 21)个月,差异有统计学意义(P<0. 05);观察组患者住院费用为(4 544. 56 ± 543. 45)元,明显少于对照组患者的(6 566. 38 ± 432. 23)元,差异有统计学意义(P<0. 05). 结论:盐酸米多君及雌二醇阴道给药对轻、中度的女性压力性尿失禁效果较好,不良反应少,可减轻患者经济负担,值得临床推广.
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