OBJECTIVE:To explore the effects of priming dexmedetomidine before rapid-sequence induction ( RIS) on intubating conditions and hemodynamics .METHODS:127 cases who underwent elective gynecologic operation for tracheal intubation under general anesthesia , admitted into the Second People's Hospital of Shaanxi from Apr .2013 to Apr.2014 were selected as the research objects;the patients were divided into observation group and control group via the random number table .The anesthesia procedure and drugs applied in the two groups were the same .0.6 μg/kg dexmedetomidine was injected before RSI to 43 cases from the observation group , while 42 cases in the control group received 10ml 0.9%sodium chloride injection .The laryngoscopic exposure grade and PaO 2 , PaCO2 during RSI were compared between the two groups .RESULTS:The proportion of Cormach ~Lehane I level in the observation group was [60.94%( 39/64 ) ] , which was significantly higher than that in the control group [ 19.05%( 12/63 ) ] , the difference was statistically significant ( P <0.05 ).The PaCO2 at the end of administration , immediately after intubation completion in observation group were higher than that in the control group [(36.43 ±4.11) mmHg,(46.90 ±4.30) mmHg VS(32.50 ±2.52) mmHg,(40.73 ±3.81) mmHg], the difference was statistically significant (P<0.05 ) .CONCLUSIONS:Priming dexmedetomidine before rapid-sequence induction can play a role of sedation without inducing respiratory inhibition , which can reduce intubation difficulty at the same time and maintain hemodynamics during intubation in stable state .It is worthy of clinical promotion .%目的：探讨快速序贯诱导（rapid-sequence induction，RSI）前预注右美托咪定对插管条件及血流动力学的影响。方法：选择陕西省第二人民医院2013年4月—2014年4月收治的127例择期妇科手术行全身麻醉气管插管患者作为研究对象，按随机数字表法分为观察组和对照组。2组患者的麻醉操作与应用药物相同，观察组64例患者实施RSI前泵注右美托咪定0.6μg／kg，对照组63例患者泵注0.9％氯化钠注射液10 ml，比较2组患者喉镜暴露分级与RSI期间血氧分压（partial pressure of oxygen，PaO2）、动脉血二氧化碳分压（artial pressure of carbon dioxide in artery， PaCO2）变化情况。结果：观察组患者Cormach～LehaneⅠ级为60.94％（39／64），明显高于对照组的19.05％（12／63），差异有统计学意义（P＜0.05）；观察组患者给药结束即刻、插管完成即刻的PaCO2为（36.43±4.11）、（46.90±4.30） mmHg，均高于对照组的（32.50±2.52）、（40.73±3.81） mmHg，差异有统计学意义（P＜0.05）。结论：快速序贯诱导前预注右美托咪定可在不引起呼吸抑制情况下发挥镇静作用，降低插管难度，使插管期间血流动力学维持平稳，值得临床推广。
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