目的：对某二级医院围术期抗菌药物的使用情况进行合理性判断与分析。方法：从该院2012年7月—2013年7月的出院病历中抽取194例手术病例，以卫生部《抗菌药物临床应用指导原则》为判断标准，结合2013年美国医院药师协会（ ASHP）指南，对围术期抗菌药物的使用率、用药时机及疗程、药物选择及用法、用量等相关指标进行综合评价。结果：Ⅰ类切口手术抗菌药物使用率为57.14％，术前用药时机的正确率达87.50％；Ⅱ类切口手术用药时机的正确率为30.00％；各类切口手术的术后用药疗程普遍较长；在抗菌药物的选择及用法用量方面较为合理。结论：医院围术期抗菌药物使用情况与国内外同类报道类似，围术期抗菌药物使用在使用率、用药时机及术后疗程方面存在部分不合理情况，需加以改进。%OBJECTIVE:To analyze the perioperative antibiotic use in patients from a secondary hospital. METHODS:194 surgical cases were randomly selected from the medical records of the patients discharged from this hospital from July 2012 to July 2013.The related indexes including the rate of antibiotic use, timing and duration of antibiotic use, choice, dosage and administration of antibiotics were assessed according to the standards developed by the Ministry of Health and the Guideline for American Society of Hospital Pharmacists ( ASHP) in 2013.RESULTS:The antibiotics were used in 57.14%of those undergoing type I incision operations and the timing of administration of antibiotics was correct in 87.50%; the timing of administration of antibiotics was correct in 30.00% in those undergoing type II incision operations.The postoperative duration of antibiotic use was generally too long for the patients either undergoing type I or type II incision operations.The antibiotic use was rational in drug choice, dosage and administration.CONCLUSIONS:The perioperative antibiotic use in this hospital was similar to that reported both at home and abroad.Irrational antibiotic use was noted in some cases in the rate of antibiotic use, timing and postoperative duration of antibiotic use, which thus remains to be improved.
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