目的：分析某二级医院2011—2013年住院患者抗菌药物的使用强度（ AUD），为临床合理使用抗菌药物提供参考。方法：回顾性分析该医院2011—2013年抗菌药物使用记录，以限定日剂量（DDD）为单位，计算抗菌药物的使用频度（DDDs）和AUD。结果：该医院2011—2013年住院患者抗菌药物的AUD分别是65.30、55.76、54.33 DDDs／（100人· d），呈逐年下降趋势。其中，青霉素类、青霉素＋β-内酰胺酶抑制剂、第1代头孢菌素类的AUD逐年下降，而第3代头孢、头孢菌素类＋β-内酰胺酶抑制剂、氟喹诺酮类、咪唑衍生物呈上升趋势。结论：该医院抗菌药物应用仍存在一些问题，住院患者的AUD较高，第3代头孢菌素和氟喹诺酮类抗菌药物的AUD增长过快，医院管理部门需进一步加强抗菌药物管理，促进临床合理用药。%OBJECTIVE:To analyze the antibiotic use density ( AUD ) in the inpatients from a secondary hospital during 2011-2013 period for clinical reference of rational use of antibiotics.METHODS:The utilization data of antibiotics in our hospital during 2011-2013 period was analyzed retrospectively with DDDs and AUD analyzed taking defined daily dose (DDD) as unit.RESULTS:The AUD of antibiotics in the inpatients from 2011 to 2013 stood at 65.30, 55.76 and 54.33 DDDs/100 persons/day respectively, assuming downward trend.The AUD of penicillin, penicillin +enzyme inhibitors and first-generation cephalosporin showed a downward trend, however, the DDD of three generation cephalosporin, cephalosporins +enzyme inhibitors, quinolones and imidazole derivatives showed an upward trend. CONCLUSIONS:The problems encountered in the use of antibiotics in the inpatients of this hospital included high AUD, excessively rapid increase in the AUD of third generation cephalosporin and quinolones; it is urgent for hospital management department to tighten monitoring on the use of antibiotics to promote clinical rational use of drugs.
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