OBJECTIVE: To probe into the efficacy of donepezil combined with hyperbaric oxygen therapy (HBOT) in treatment of vascular dementia and its effect on patients' cognitive function. METHODS: 60 patients with vascular dementia admitted into Nanhai Hospital of Guangdong General Hospital from Apr. 2014 to Oct. 2017 were selected and divided into control group and observation group via random number table, with 30 cases in each group. The control group was given piracetam combined with HBOT, while the observation group was given donepezil combined with HBOT. Differences in mini mental status examination (MMSE), Blessed-Roth scores, scores of activity of daily living scale (ADL), clinical efficacy and incidences of adverse drug reactions between two groups were compared. RESULTS: After treatment, the MMSE, Blessed-Roth and ADL scores of both groups had been significantly improved, and those of observation group were significantly better than the control group, with statistically significant differences (P＜0.05); the total effective rate of observation group was 86.67％ (26/30), which was significantly higher than that of the control group (56.67％, 17/30), with statistically significant difference (P＜0.05); the incidences of adverse drug reactions of observation group and control group were respectively 6.67％ (2/30) and 10.00％ (3/30), the difference had no statistical significance (P＞0.05). The condition of both groups were controlled after symptomatic treatment. CONCLUSIONS: The efficacy of donepezil combined with HBOT in treatment of vascular dementia is remarkable, which can effectively improve patients' cognitive function and quality of life, with high safety.%目的:探讨多奈哌齐联合高压氧疗法治疗血管性痴呆的疗效及对患者认知能力的影响.方法:选取2014年4月至2017年10月广东省人民医院南海医院收治的血管性痴呆患者60例, 采用随机数字表法分为对照组和观察组, 每组30例.对照组患者给予吡拉西坦联合高压氧治疗, 观察组患者给予多奈哌齐联合高压氧治疗.比较两组患者简易精神状态检查表 (mini mental status examination, MMSE) 评分、Blessed-Roth评分、日常生活能力量表 (activity of daily living scale, ADL) 评分、临床疗效及不良反应发生情况的差异.结果:治疗后, 两组患者MMSE、Blessed-Roth和ADL评分较治疗前明显改善, 且观察组患者明显优于对照组, 差异均有统计学意义 (P＜0.05);观察组患者的总有效率为86.67％ (26/30), 明显高于对照组的56.67％ (17/30), 差异有统计学意义 (P＜0.05);观察组、对照组患者不良反应发生率分别为6.67％ (2/30) 、10.00％ (3/30), 差异无统计学意义 (P＞0.05), 对症处理后均得到控制.结论:多奈哌齐联合高压氧疗法治疗血管性痴呆的疗效显著, 能够明显改善患者的认知能力, 提高生活质量, 且安全性较高.
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