Using ultrasonic-assisted alkali extraction-acid precipitation extracts Pleurotus FerulaeLenzi protein, and optimizing extraction conditions through response surface methodology. In single-factor,based on the Central Composite design principles, utilizing Design-Expert.8.05 data analysis software, three factors and five levels of optimization analysis were applying on Extraction of Pleurotus FerulaeLenzi Protein. The optimum extraction conditions:pH10, extraction temperature 27.09℃,extraction time 9.45 min, liquid ratio 5,the extraction ratio was 17.68%.%利用超声波辅助碱溶酸沉提取阿魏菇蛋白，并通过响应面法优化提取条件。在单因素的基础上，根据Central Composite中心组合设计原理，运用Design-Expert.8.05数据分析软件，对阿魏菇蛋白提取进行了三因素五水平的优化分析。确定的最佳提取条件：pH10、超声温度27.09℃、超声时间9.45 min、液料比5，在此条件下的蛋白提取率的理论值达到17.68%。
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