To investigate the effect of vitamin C intervention on cadmium induced erythrocyte micronucleus of Carassius au-ratus, with the 0.5 mg/L cadmium solution as the control group , the 0.5 mg/L cadmium solution separately added 1 g, 2 g, 3 g/L of vitamin C(VC) were as experimental group.Firstly, C.auratus were separately exposure 5, 10, 15, 20 d. Then, blood smears were taken from crucian carp tail blood , microscopic examination , and the erythrocyte micronucleus rate was measured .The results showed that the erythrocyte micronucleus rate induced by cadmium increased linearly with time in the control group, y=0.158 7 X+2.516 7 (R2 =0.935 7).However, in the experimental group, the erythro-cyte micronucleus rate decreased with vitamin C concentration increasing and treatment time .The micronucleus rate was lowest for the experimental group with 3 g/L vitamin C and treating 20 d, and only 0.26%; contrast to the control group treating 20 d, control rate of micronucleus was 95.62%.The T-test results showed that the effect of vitamin C intervention on cadmium induced erythrocyte micronucleus rate was significant ( t>t0.01 ) , the effect increased with vitamin C concen-tration increasing .%为探究维生素C对镉导致鲫（ Carassius auratus）红细胞微核的干预作用，用0.5 mg/L的镉溶液单一染毒作对照组，设置0.5 mg/L的镉溶液分别添加1、2、3 g/L的维生素C（ VC）三组作为实验组。在染毒后的第5、10、15、20天分别取鲫尾部血液制作血涂片，镜检并统计红细胞微核率。结果显示：0.5 mg/L的镉溶液单一染毒对照组，镉诱发鲫红细胞产生微核率与时间呈现线性关系，回归函数为： y＝0.1587 x＋2.5167（ R2＝0.9357）；实验组随着VC浓度增加和处理时间的延长，微核率降低，其中以0.5 mg/L Cd2＋＋3 g/L VC组处理20 d的微核率最低，微核率为仅为0.26‰，与处理20 d的对照组相比，微核抑制率达到95.62％。 T检验分析表明， VC对镉导致鲫鱼红细胞微核干预作用极显著（ t＞t0.01），干预作用在试验中呈现出随VC浓度增加干预作用增强的趋势。实验表明， VC对镉导致鲫红细胞微核率升高的现象有明显的干预作用。
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