Objective To identify the best condition of liver protection by observing the volume -effect relationship of different doses of 2∶1 ratio compatibility of hovenia dulcis thunb and flower of kudzu-vine after liquor solution. Methods 56° hongxing erguotou liquor was used to lavage the six groups to es-tablish the chronic alcoholic liver injury animal models. According to the weight, the male Wistar rats were randomly divided into six groups: blank group, model group, dongbao gantai controlled group, high dose group, moderate dose group and low dose group of 2∶1 compatibility flower of kudzuvine and hovenia dulcis thunb. The blood was taken from abdominal aorta after 4 weeks, 8 weeks and 12 weeks respectively, then 0. 2g of the left hepatic lobe was also taken to detect the concentration of ethanol in blood and liver alcohol dehydrogenase activity. Results Administration of 8 weeks and 12 weeks, different doses of flower of kud-zuvine and hovenia dulcis thunb can reduce the blood compatibility of ethanol concentration, enhance the activities of ADH in liver. Findings show that low dose group outweighs other groups in terms of effica-cy. Conclusion Findings also indicate that different doses of hovenia dulcis thunb and flower of kudzuvine compatibility can protect liver, but the best model is the low dose group, and the longer medicine adminis-tration, the better efficacy it will be.%目的：观察不同剂量葛花、枳椇子2∶1比例配伍后解酒保肝的量时效关系,明确葛花枳椇子配伍使用的最佳条件。方法采用56°红星二锅头白酒灌胃复制慢性酒精性肝损伤动物模型的方法,将Wistar雄性大鼠,按体重随机分为六组：空白组,模型组,东宝肝泰对照组,葛花枳椇子2∶1高剂量配伍组,葛花枳椇子2∶1中剂量配伍组,葛花枳椇子2∶1低剂量配伍组,于实验4周、8周、12周末分别取材,腹主动脉取血,并迅速取肝左叶组织约0．2 g,检测血中乙醇浓度以及肝中乙醇脱氢酶活性。结果给药8周和12周,葛花枳椇子各剂量配伍组均可降低血中乙醇浓度,增强肝中乙醇脱氢酶活性,且配伍低剂量组较其他组有一定的治疗优势。结论结果表明,不同剂量葛花、枳椇子比例配伍均有一定程度解酒保肝功效,但葛花、枳椇子2∶1比例低剂量配伍效果最佳,随着给药时间的延长治疗效果越好。
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