表雄酮是激素类药物中的重要中间体。本研究以华南地区丰富的剑麻皂素为起始原料，经乙酰基保护、开环、氧化、水解、消除得到单烯醇酮醋酸酯，然后经肟化、Bechmann 重排和水解得到表雄甾酮，整个研究采用类似一锅法得到目标产物，收率高。%3β-Acetoxy-5a-androstan-17-one is an important intermediate in the hormone drugs. This paper was to use the tigogenin as the raw material to gain single enol ketone acetate by acetyl protection, ring-opening, oxidation,hydrolysis and elimination reaction, and then to further get 3β-Acetoxy-5a-androstan-17-one through oximation, Bechmann rearrengement and hydrolysis. The whole research utilized the similar one-pot reaction method to obtain our final preparation with a high yield.
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